Trichloroethylene Dose Response Assessment: Additional Issues Relevant for a Scientifically Credible Approach
نویسندگان
چکیده
Several issues associated with the hazard identification and dose response assessment of trichloroethylene are discussed. These issues include the identification of TCE’s critical effect and overall cancer weight of evidence, the use of the recently harmonized TCE PBPK model for improving extrapolations from experimental animal to humans, an understanding of uncertainty in dose response assessment, and use of differing cancer slope factors in risk management decisions. Based on this discussion and analyses, we suggest research that might both ameliorate several of the uncertainties in the assessment of TCE’s risk and provide a foundation for an international effort at harmonization of disparate dose response assessment values.
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